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Phone
Phone
John Doe

Detailed Programme
Wednesday 15.5.2024, Simulation Centre of Masaryk University (SIMU)
  • 15:00 – 19:00 Registration
  • 16:00 – 18:00 High Fidelity Hands-on Simulation Workshop organised by EMHG Young members for anaesthesia or ICU doctors/nurses or medical students (pre-registered only)
  • 17:15 – 19:00 SIMU guided tour 1 + Simulation Workshop ‘How we teach managing of the MH crisis’*
  • 18:15 – 19:00 SIMU guided tour 2*
  • 19:00 – 22:00 Welcome drink and buffet on the roof of SIMU*

    • The workshops require registration to provide the best possible experience in the Simulation Centre. More information is in the bookmark “SIMU”.

Thursday 16.5.2024, Hotel International Brno
  • 7:45 – 9:30 Registration
  • 8:00 - 9:20 Board of Directors Meeting (by invitation only)
  • 9:30 – 9:50 EMHG Annual Meeting 2024 Opening
  • 9:50 – 10:45 IVCT Masterclass - Young Members Session for everybody

    Chairs: Martina Klincová, Stephan Johannsen

    1. IVCT basics – Stephan Johannsen (15 min)
    2. IVCT Troubleshooting with discussion - Henrik Rüffert (40 min)

  • 10:45 – 11:15 coffee break

  • 11:15 – 12:15 Honorary guest lecture – prof. Šárka Pospíšilová, Brno, Czechia
    From the founder of genetics, Gregor Johann Mendel, to the current challenges of genomics.

  • 12:15 – 13:00 Scientific Session 1

    Chairs: Petr Štourač, Thierry Girard

    1. Importance of the new comprehensive electronic Czech and Slovak Malignant Hyperthermia Registry for improvement of workflow and counselling - Dagmar Štěpánková (15 min)
    2. Malignant Hyperthermia Event Registry - Thierry Girard (15 min)
    3. Patient empowerment of MHS Individuals using artificial intelligence - Albert Urwyler (15 min)
  • 13:00 – 14:00 lunch

  • 14:00 – 15:15 Scientific Session 2

    Chairs: Kathryn Stowell, Erik-Jan Kamsteeg

    1. Revisiting Diagnostic Mutations in Malignant Hyperthermia: A Retrospective Analysis in Individuals Investigated by In Vitro Contracture Testing – Karin Dreisig (15 min)
    2. Evaluation of genetic variants in the RYR1, CACNA1S and STAC3 genes to estimate the genetic prevalence of malignant hyperthermia with data sets from the Leipzig Institute of Human Genetics – Börge Bastian (15 min)
    3. Long Read Sequencing of RYR1 Haplotypes in Malignant Hyperthermia Families – Mohammad Saleh (15 min)
    4. A preliminary burden analysis of rare variants in UK malignant hyperthermia exomes – Phil Hopkins (15 min)
  • 16:15 Bus to Mendel Museum
  • 16:30 – 19:00 Guided J. G. Mendel Museum exhibition tour*
  • 19:30 – 22:30 Gala dinner in J. G. Mendel´s Greenhouse*
Friday 17.5.2024, Hotel International Brno
  • 8:30 – 10:00 Scientific Session 3

    Chairs: Anna Hellblom, Jonathan Bilmen

    1. Greater frequency of joint dislocation in malignant hyperthermia susceptible patients: case-control observational study – Helga da Silva (15 min)
    2. A case from the Emergency Hotline of the Malignant Hyperthermia Association of the United States. Presentation, Treatment and the Challenge of Definitive Diagnosis – Dorothea Hall (15 min)
    3. Preoperative use of anabolic androgenic steroids and illicit drugs as modifying factors in Malignant Hyperthermia? – Mary dos Santos Silva (15 min)
    4. Functional consequences of MH-causative RYR1 mutations on the immune system – Huiying Li (15 min)
    5. Malignant Hyperthermia Triggered by Ether Anesthesia in 1954? – Mark Poler (15 min)
  • 10:00 – 10:30 coffee break

  • 10:30 – 12:00 Scientific Session 4

    Chairs: Kathryn Stowell, Henrik Rüffert

    1. Propofol directly binds and inhibits skeletal muscle ryanodine receptor 1 – Thomas T. Joseph (15 min)
    2. Investigating the sensitivity of the myotubes derived from Malignant Hyperthermia Susceptibility patients with novel CACNA1S gene variants to RyR1 agonists induced calcium release – Yuko Noda (15 min)
    3. The Cav1.1 pT1009K variant reveals that the enhanced resting extracellular Ca2+ entry is conserved across variants in different key proteins involved in malignant hyperthermia – John Wylde (15 min)
    4. Generation of a Stac3 p.W280S knock-in mouse: initial findings – Christine Diggle (15 min)
    5. Muscle stiffness during exercise – evaluation of MHS and MHN probands by shear wave elastography – Benedikt Lother (15 min)
  • 12:00 – 13:00 Honorary guest lecture – Robert T. Dirksen, New York, USA
    The impact of humidity and heat pre-exposure on susceptibility to an MH event.

  • 13:00 – 14:00 lunch

  • 14:00 – 15:00 Scientific Session 5

    Chairs: Sheila Riazi, Klaus Glahn

    1. Assessing the Muscle Metabolome in Malignant Hyperthermia – Helena Kim (15 min)
    2. The first approach towards Non-Invasive Diagnosis of Malignant Hyperthermia: porcine animal model – Oscar Diaz-Cambronero (15 min)
    3. Towards Non-Invasive Diagnosis of Malignant Hyperthermia: Biomarker Discovery – Carlos A. Ibarra Moreno (15 min)
  • 15:00 – 16:00 Clinical Counselling Masterclass - Young Members Session for everybody
    Members of the panel discussion: Thierry Girard, Phil Hopkins, Sheila Riazi, Klaus Glahn, Erik-Jan Kamsteeg, Henrik Rüffert, Robyn Gillies; Moderator: Martina Klincová

    Short interactive case reports with a panel discussion on MH diagnostics and clinical counselling.

  • 16:00 – 17:00 Annual General Meeting, Awards, End of the Meeting

  • 18:00 – 19:00 Brno city walking tour (optional) *
  • 19:30 – 24:00 Brno social dinner (optional) *

    • *Accompanying persons are welcome